Nature Reviews Endocrinology, Published online: 11 November 2024; doi:10.1038/s41574-024-01064-xA patient with longstanding type 1 diabetes mellitus has achieved insulin independence for at least 1 year after transplantation of autologous stem cell islets. These cells were differentiated from inducible pluripotent stem cells from adipose tissue and were transplanted into the rectus sheath of the abdominal wall.

Nature Reviews Endocrinology, Published online: 08 November 2024; doi:10.1038/s41574-024-01065-wHighlights from the Joint Irish–UK Endocrine Meeting 2024

Nature Reviews Endocrinology, Published online: 05 November 2024; doi:10.1038/s41574-024-01060-1Intricacies and obscurities of non-shivering thermogenesis

Nature Reviews Endocrinology, Published online: 28 October 2024; doi:10.1038/s41574-024-01056-xAlthough science is becoming ever more complex, interdisciplinary and open, the scientific publication process has largely remained static, which affects the integrity and impact of articles. At the 2023 Danish Diabetes and Endocrine Academy Postdoc Summit, we identified five aspects of this process that need attention to enable reform.

Nature Reviews Endocrinology, Published online: 11 November 2024; doi:10.1038/s41574-024-01064-xA patient with longstanding type 1 diabetes mellitus has achieved insulin independence for at least 1 year after transplantation of autologous stem cell islets. These cells were differentiated from inducible pluripotent stem cells from adipose tissue and were transplanted into the rectus sheath of the abdominal wall.

Nature Reviews Endocrinology, Published online: 08 November 2024; doi:10.1038/s41574-024-01065-wHighlights from the Joint Irish–UK Endocrine Meeting 2024

Nature Reviews Endocrinology, Published online: 05 November 2024; doi:10.1038/s41574-024-01060-1Intricacies and obscurities of non-shivering thermogenesis

Nature Reviews Endocrinology, Published online: 28 October 2024; doi:10.1038/s41574-024-01056-xAlthough science is becoming ever more complex, interdisciplinary and open, the scientific publication process has largely remained static, which affects the integrity and impact of articles. At the 2023 Danish Diabetes and Endocrine Academy Postdoc Summit, we identified five aspects of this process that need attention to enable reform.

Nature Reviews Gastroenterology & Hepatology, Published online: 11 November 2024; doi:10.1038/s41575-024-01004-0The microbiota is critical for metabolic health. Studies published in 2024 have revealed mechanisms by which key bacterial and micro-eukaryotic organisms optimize energy production in our body and ensure efficient metabolic function.

Nature Reviews Gastroenterology & Hepatology, Published online: 04 November 2024; doi:10.1038/s41575-024-00996-zLymphatic vessels are important for fluid absorption and immune cell transport. This Review discusses the role of the intestinal lymphatic system in transport and inter-organ communication, exploring lipid absorption mechanisms, gut microenvironment influences, immune cell trafficking and intestinal lymphatics as a drug delivery system.

Nature Reviews Gastroenterology & Hepatology, Published online: 28 October 2024; doi:10.1038/s41575-024-01005-zType 2 taste receptors (Tas2rs in mice and TAS2Rs in humans) detect bitter stimuli and are present in both the oral cavity and extraoral sites. In this Review, the authors discuss Tas2rs/TAS2Rs in the gastrointestinal enteroendocrine system and how they could be potential targets to prevent or treat metabolic disorders.

Nature Reviews Gastroenterology & Hepatology, Published online: 11 November 2024; doi:10.1038/s41575-024-01004-0The microbiota is critical for metabolic health. Studies published in 2024 have revealed mechanisms by which key bacterial and micro-eukaryotic organisms optimize energy production in our body and ensure efficient metabolic function.

Nature Reviews Gastroenterology & Hepatology, Published online: 04 November 2024; doi:10.1038/s41575-024-00996-zLymphatic vessels are important for fluid absorption and immune cell transport. This Review discusses the role of the intestinal lymphatic system in transport and inter-organ communication, exploring lipid absorption mechanisms, gut microenvironment influences, immune cell trafficking and intestinal lymphatics as a drug delivery system.

Nature Reviews Gastroenterology & Hepatology, Published online: 28 October 2024; doi:10.1038/s41575-024-01005-zType 2 taste receptors (Tas2rs in mice and TAS2Rs in humans) detect bitter stimuli and are present in both the oral cavity and extraoral sites. In this Review, the authors discuss Tas2rs/TAS2Rs in the gastrointestinal enteroendocrine system and how they could be potential targets to prevent or treat metabolic disorders.

Nature Reviews Nephrology, Published online: 22 October 2024; doi:10.1038/s41581-024-00904-3Treating AAV by targeting T cell responses

Nature Reviews Nephrology, Published online: 22 October 2024; doi:10.1038/s41581-024-00897-zCongenital nephrogenic diabetes insipidus is a rare but potentially life-threatening condition. This Consensus Statement provides clinical practice recommendations developed by the European Reference Network on Rare Kidney Diseases, the European Society for Paediatric Nephrology and patient advocates to support clinicians in the diagnosis, treatment and genetic counselling of children and adults with nephrogenic diabetes insipidus.

Nature Reviews Nephrology, Published online: 03 October 2024; doi:10.1038/s41581-024-00895-1The Neonatal Kidney Collaborative is a multidisciplinary initiative that aims to improve neonatal kidney health. By uniting experts and promoting trainees from various fields, the collaborative has developed a strong foundation for research, education and advocacy efforts that will advance our understanding and treatment of kidney problems in newborns.

Nature Reviews Nephrology, Published online: 22 October 2024; doi:10.1038/s41581-024-00904-3Treating AAV by targeting T cell responses

Nature Reviews Nephrology, Published online: 22 October 2024; doi:10.1038/s41581-024-00897-zCongenital nephrogenic diabetes insipidus is a rare but potentially life-threatening condition. This Consensus Statement provides clinical practice recommendations developed by the European Reference Network on Rare Kidney Diseases, the European Society for Paediatric Nephrology and patient advocates to support clinicians in the diagnosis, treatment and genetic counselling of children and adults with nephrogenic diabetes insipidus.

Nature Reviews Nephrology, Published online: 03 October 2024; doi:10.1038/s41581-024-00895-1The Neonatal Kidney Collaborative is a multidisciplinary initiative that aims to improve neonatal kidney health. By uniting experts and promoting trainees from various fields, the collaborative has developed a strong foundation for research, education and advocacy efforts that will advance our understanding and treatment of kidney problems in newborns.

Nature Neuroscience, Published online: 11 November 2024; doi:10.1038/s41593-024-01777-2Tyrosine kinase 2 (TYK2) critically regulates tau levels and aggregation by phosphorylating tau’s tyrosine 29. Partial inhibition of TYK2 mitigates tau pathologies in cells and mice, highlighting TYK2 as a potential therapeutic target for Alzheimer’s disease and other tauopathies.

Nature Neuroscience, Published online: 05 November 2024; doi:10.1038/s41593-024-01798-xIn this issue, Alsema, Wijering, Miedema, Kotah et al. and Lerma-Martin, Badia-i-Mompel et al. demonstrate the ever-growing possibilities of spatial transcriptomics by applying it to the spatially heterogeneous disease multiple sclerosis. They validate the technique by comparison to classic pathology and reveal insights into demyelinated lesion markers, pathological cell types and lesion evolution.

Nature Neuroscience, Published online: 05 November 2024; doi:10.1038/s41593-024-01765-6Lesion initiation and progression in multiple sclerosis is a dynamic but unclear process. Here, the authors highlight cell type-specific gene sets characterizing the action lesion rims and identify trajectories, predicting how normal-appearing white matter can develop into active and mixed active/inactive lesions.

Nature Reviews Rheumatology, Published online: 07 November 2024; doi:10.1038/s41584-024-01179-5BCR-independent memory B cell reactivation via TLR7 or TLR8 activation, type I interferon production, immune complex formation and T helper cell signalling is central in SLE pathogenesis. Dörner and Lipsky discuss the potential of targeting these pathways to eliminate autoreactive memory B cells and plasma cells in SLE.

Nature Reviews Rheumatology, Published online: 05 November 2024; doi:10.1038/s41584-024-01186-6In an open-label clinical trial, collagenase injection was not noninferior to limited fasciectomy for the treatment of Dupuytren contracture.

Nature Reviews Rheumatology, Published online: 30 October 2024; doi:10.1038/s41584-024-01178-6In this Review, López and Gualillo discuss the complex interrelationships between rheumatic diseases and the hypothalamic and autonomic mechanisms that regulate metabolism, and explore the therapeutic potential of targeting central regulators of energy balance.

Nature Reviews Rheumatology, Published online: 07 November 2024; doi:10.1038/s41584-024-01179-5BCR-independent memory B cell reactivation via TLR7 or TLR8 activation, type I interferon production, immune complex formation and T helper cell signalling is central in SLE pathogenesis. Dörner and Lipsky discuss the potential of targeting these pathways to eliminate autoreactive memory B cells and plasma cells in SLE.

Nature Reviews Rheumatology, Published online: 05 November 2024; doi:10.1038/s41584-024-01186-6In an open-label clinical trial, collagenase injection was not noninferior to limited fasciectomy for the treatment of Dupuytren contracture.

Nature Reviews Rheumatology, Published online: 30 October 2024; doi:10.1038/s41584-024-01178-6In this Review, López and Gualillo discuss the complex interrelationships between rheumatic diseases and the hypothalamic and autonomic mechanisms that regulate metabolism, and explore the therapeutic potential of targeting central regulators of energy balance.

Nature Reviews Urology, Published online: 14 November 2024; doi:10.1038/s41585-024-00962-zIn this Review, the authors provide an overview of molecular imaging in renal cell carcinoma, discussing the role of molecular imaging approaches in renal cell carcinoma diagnosis, treatment and response monitoring.

Nature Reviews Urology, Published online: 13 November 2024; doi:10.1038/s41585-024-00968-7Metabolism, mitochondria and metastasis in kidney cancer

Nature Reviews Urology, Published online: 11 November 2024; doi:10.1038/s41585-024-00971-yTivozanib monotherapy outperforms combination therapy in post-ICI RCC

Nature Reviews Urology, Published online: 11 November 2024; doi:10.1038/s41585-024-00952-1High-fat diets disrupt testicular function by accumulating lipids, impairing sperm production and affecting the cytoskeleton of spermatogenic cells. This Perspective aims to understand these mechanisms to develop treatments for infertility in men with obesity.

Nature Reviews Urology, Published online: 14 November 2024; doi:10.1038/s41585-024-00962-zIn this Review, the authors provide an overview of molecular imaging in renal cell carcinoma, discussing the role of molecular imaging approaches in renal cell carcinoma diagnosis, treatment and response monitoring.

Nature Reviews Urology, Published online: 13 November 2024; doi:10.1038/s41585-024-00968-7Metabolism, mitochondria and metastasis in kidney cancer

Nature Reviews Urology, Published online: 11 November 2024; doi:10.1038/s41585-024-00971-yTivozanib monotherapy outperforms combination therapy in post-ICI RCC

Nature Reviews Urology, Published online: 11 November 2024; doi:10.1038/s41585-024-00952-1High-fat diets disrupt testicular function by accumulating lipids, impairing sperm production and affecting the cytoskeleton of spermatogenic cells. This Perspective aims to understand these mechanisms to develop treatments for infertility in men with obesity.