Nature Reviews Cardiology, Published online: 14 November 2024; doi:10.1038/s41569-024-01099-7Debate exists regarding the best terminology for common presentations of heart diseases caused by epicardial and/or microvascular coronary artery disease with or without myocardial ischaemia. In this Comment, we discuss the pros and cons of a new proposal to replace the vessel-based nomenclature of acute and chronic coronary syndromes with the myocardial-oriented nomenclature of acute and non-acute myocardial ischaemic syndromes.

Nature Reviews Cardiology, Published online: 13 November 2024; doi:10.1038/s41569-024-01097-9In this Review on cardiodermatology, Gelfand and colleagues discuss specific skin findings associated with cardiovascular diseases, important cutaneous adverse effects of common cardiovascular therapies, and the effects of dermatological diseases and dermatological treatment on cardiovascular risk.

Nature Reviews Cardiology, Published online: 05 November 2024; doi:10.1038/s41569-024-01094-yIn this Review, Tao and colleagues discuss the design and applications of nanoparticles and nanofabricated biomaterials, such as hydrogels, external graft support devices and cell-based therapies, for the treatment of vein graft disease and highlight the potential of using these nanofabricated biomaterials alongside bypass surgery to improve local delivery efficiency and therapeutic efficacy.

Nature Reviews Cardiology, Published online: 23 October 2024; doi:10.1038/s41569-024-01092-0In this Tools of the Trade article, Bodagh and Williams highlight the utility of OpenEP, an open-source platform that offers standardized solutions for storage and analysis of electroanatomic mapping data.

Nature Reviews Clinical Oncology, Published online: 06 November 2024; doi:10.1038/s41571-024-00963-2The DESTINY-Breast06 trial investigated earlier and broader use of trastuzumab deruxtecan in patients with metastatic hormone-receptor-positive breast cancer, and demonstrated improvements in progression-free survival over standard chemotherapy. These data provide a meaningful advance; however, this strategy might not be right for all patients, and careful consideration is recommended before blanket use.

Nature Reviews Clinical Oncology, Published online: 01 November 2024; doi:10.1038/s41571-024-00956-1In several B cell malignancies, BTK is a crucial mediator of oncogenic signalling pathways and inhibitors of this kinase have substantially improved patient outcomes. This Review discusses the currently approved indications for covalent and non-covalent BTK inhibitors, as well as mechanisms of resistance, and novel BTK-targeted agents and treatment strategies that have the potential to further improve outcomes.

Nature Reviews Clinical Oncology, Published online: 25 October 2024; doi:10.1038/s41571-024-00962-3Cadonilimab is effective and safe in recurrent cervical cancer

Nature Reviews Clinical Oncology, Published online: 25 October 2024; doi:10.1038/s41571-024-00953-4Reply to ‘NALIRIFOX in the frontline for metastatic pancreatic cancer: evidence beyond NAPOLI 3’

Nature Reviews Endocrinology, Published online: 11 November 2024; doi:10.1038/s41574-024-01064-xA patient with longstanding type 1 diabetes mellitus has achieved insulin independence for at least 1 year after transplantation of autologous stem cell islets. These cells were differentiated from inducible pluripotent stem cells from adipose tissue and were transplanted into the rectus sheath of the abdominal wall.

Nature Reviews Endocrinology, Published online: 08 November 2024; doi:10.1038/s41574-024-01065-wHighlights from the Joint Irish–UK Endocrine Meeting 2024

Nature Reviews Endocrinology, Published online: 05 November 2024; doi:10.1038/s41574-024-01060-1Intricacies and obscurities of non-shivering thermogenesis

Nature Reviews Endocrinology, Published online: 28 October 2024; doi:10.1038/s41574-024-01056-xAlthough science is becoming ever more complex, interdisciplinary and open, the scientific publication process has largely remained static, which affects the integrity and impact of articles. At the 2023 Danish Diabetes and Endocrine Academy Postdoc Summit, we identified five aspects of this process that need attention to enable reform.

Nature Reviews Gastroenterology & Hepatology, Published online: 11 November 2024; doi:10.1038/s41575-024-01004-0The microbiota is critical for metabolic health. Studies published in 2024 have revealed mechanisms by which key bacterial and micro-eukaryotic organisms optimize energy production in our body and ensure efficient metabolic function.

Nature Reviews Gastroenterology & Hepatology, Published online: 04 November 2024; doi:10.1038/s41575-024-00996-zLymphatic vessels are important for fluid absorption and immune cell transport. This Review discusses the role of the intestinal lymphatic system in transport and inter-organ communication, exploring lipid absorption mechanisms, gut microenvironment influences, immune cell trafficking and intestinal lymphatics as a drug delivery system.

Nature Reviews Gastroenterology & Hepatology, Published online: 28 October 2024; doi:10.1038/s41575-024-01005-zType 2 taste receptors (Tas2rs in mice and TAS2Rs in humans) detect bitter stimuli and are present in both the oral cavity and extraoral sites. In this Review, the authors discuss Tas2rs/TAS2Rs in the gastrointestinal enteroendocrine system and how they could be potential targets to prevent or treat metabolic disorders.

Nature Reviews Nephrology, Published online: 22 October 2024; doi:10.1038/s41581-024-00904-3Treating AAV by targeting T cell responses

Nature Reviews Nephrology, Published online: 22 October 2024; doi:10.1038/s41581-024-00897-zCongenital nephrogenic diabetes insipidus is a rare but potentially life-threatening condition. This Consensus Statement provides clinical practice recommendations developed by the European Reference Network on Rare Kidney Diseases, the European Society for Paediatric Nephrology and patient advocates to support clinicians in the diagnosis, treatment and genetic counselling of children and adults with nephrogenic diabetes insipidus.

Nature Reviews Nephrology, Published online: 03 October 2024; doi:10.1038/s41581-024-00895-1The Neonatal Kidney Collaborative is a multidisciplinary initiative that aims to improve neonatal kidney health. By uniting experts and promoting trainees from various fields, the collaborative has developed a strong foundation for research, education and advocacy efforts that will advance our understanding and treatment of kidney problems in newborns.

Nature Reviews Neurology, Published online: 13 November 2024; doi:10.1038/s41582-024-01039-6Dementia risk scores in diverse populations

Nature Reviews Neurology, Published online: 13 November 2024; doi:10.1038/s41582-024-01044-9Sex differences in Alzheimer disease could be influenced by differences in immune responses, new research suggests.

Nature Reviews Neurology, Published online: 04 November 2024; doi:10.1038/s41582-024-01034-xParkinson disease (PD) poses substantial management challenges owing to progressive disability and emergence of levodopa-resistant symptoms and treatment-related complications. This Review examines the current state of research into symptomatic and disease-modifying PD therapies and outlines future priorities for advancing our understanding and treatment of the disease.

Nature Reviews Neurology, Published online: 14 October 2024; doi:10.1038/s41582-024-01031-0BCAS1+ oligodendrocytes aid remyelination in MS

Nature Reviews Rheumatology, Published online: 07 November 2024; doi:10.1038/s41584-024-01179-5BCR-independent memory B cell reactivation via TLR7 or TLR8 activation, type I interferon production, immune complex formation and T helper cell signalling is central in SLE pathogenesis. Dörner and Lipsky discuss the potential of targeting these pathways to eliminate autoreactive memory B cells and plasma cells in SLE.

Nature Reviews Rheumatology, Published online: 05 November 2024; doi:10.1038/s41584-024-01186-6In an open-label clinical trial, collagenase injection was not noninferior to limited fasciectomy for the treatment of Dupuytren contracture.

Nature Reviews Rheumatology, Published online: 30 October 2024; doi:10.1038/s41584-024-01178-6In this Review, López and Gualillo discuss the complex interrelationships between rheumatic diseases and the hypothalamic and autonomic mechanisms that regulate metabolism, and explore the therapeutic potential of targeting central regulators of energy balance.

Nature Reviews Urology, Published online: 14 November 2024; doi:10.1038/s41585-024-00962-zIn this Review, the authors provide an overview of molecular imaging in renal cell carcinoma, discussing the role of molecular imaging approaches in renal cell carcinoma diagnosis, treatment and response monitoring.

Nature Reviews Urology, Published online: 13 November 2024; doi:10.1038/s41585-024-00968-7Metabolism, mitochondria and metastasis in kidney cancer

Nature Reviews Urology, Published online: 11 November 2024; doi:10.1038/s41585-024-00971-yTivozanib monotherapy outperforms combination therapy in post-ICI RCC

Nature Reviews Urology, Published online: 11 November 2024; doi:10.1038/s41585-024-00952-1High-fat diets disrupt testicular function by accumulating lipids, impairing sperm production and affecting the cytoskeleton of spermatogenic cells. This Perspective aims to understand these mechanisms to develop treatments for infertility in men with obesity.