Nature Reviews Cardiology, Published online: 08 September 2026; doi:10.1038/s41569-026-01349-wTobias Lerchner and Stephane Heymans discuss the study that provided seminal evidence linking genetic variation to susceptibility to acute myocarditis.

Nature Reviews Cardiology, Published online: 02 September 2026; doi:10.1038/s41569-026-01346-zIn this Tools of the Trade, Ackers-Johnson and Pavlovic describe a Langendorff-free approach to isolate cardiomyocytes without the technical hurdles associated with the conventional Langendorff perfusion procedure.

Nature Reviews Cardiology, Published online: 02 September 2026; doi:10.1038/s41569-026-01339-yIn this Review, Eltzschig and colleagues describe the role of hypoxia-inducible factors (HIFs) in mediating cardioprotection against ischaemia–reperfusion injury and discuss the therapeutic potential of pharmacological HIF stabilizers in the settings of myocardial infarction and both cardiac and non-cardiac surgery.

Nature Reviews Cardiology, Published online: 27 August 2026; doi:10.1038/s41569-026-01344-1Bedside epicardial adipose tissue assessment in the era of advanced adipose phenotyping

Nature Reviews Clinical Oncology, Published online: 07 September 2026; doi:10.1038/s41571-026-01202-6Liver resection improves survival in patients with locally advanced HCC

Nature Reviews Clinical Oncology, Published online: 27 August 2026; doi:10.1038/s41571-026-01200-8Belzutifan plus lenvatinib delays disease progression in advanced-stage RCC

Nature Reviews Clinical Oncology, Published online: 19 August 2026; doi:10.1038/s41571-026-01190-7Despite considerable progress in other cancer types, progress with the development of targeted therapies for patients with glioblastoma has remained limited, despite considerable research effort. In this Review, the authors summarize the various attempts to develop effective targeted therapies for patients with glioblastoma, including some of the challenges that have likely impaired progress thus far. The authors also highlight novel therapies, clinical trial designs and research directions that have been informed by the shortcomings of previous research efforts, all of which might eventually lead to improved outcomes for patients.

Nature Reviews Clinical Oncology, Published online: 11 August 2026; doi:10.1038/s41571-026-01193-4PROTEUS met its amended co-primary end points but should not be interpreted as practice changing. The trial compared two experimental strategies rather than the current standard of care, relied on an unvalidated approach (prostate-specific membrane antigen-PET) for assessments of metastasis-free survival, demonstrated minimal absolute benefit with increased toxicity and lacks both mature overall survival data and sufficient data on patient-reported outcomes to support adoption.

Nature Reviews Endocrinology, Published online: 07 September 2026; doi:10.1038/s41574-026-01305-1Adjusting α-cell metabolism induces β-cell features

Nature Reviews Endocrinology, Published online: 01 September 2026; doi:10.1038/s41574-026-01300-6CheckCausesObesity.com (CCO) is a science-based screening and monitoring tool, developed by multidisciplinary experts and consistent with international guidelines. CCO systematically screens for potential obesity causes and contributing factors across seven categories, including lifestyle and medical factors, alongside selected comorbidities as well as anthropometric, demographic and socioeconomic characteristics. CCO supports individualized assessment, treatment and population-level monitoring.

Nature Reviews Endocrinology, Published online: 25 August 2026; doi:10.1038/s41574-026-01291-4This Consensus Statement provides evidence-based guidance on the clinical application of genetic tests in pituitary adenomas (focusing on germline genetic testing), with recommendations regarding genes for inclusion in panel testing, test indications, pre-test counselling, test methodologies, and result interpretation and follow-up.

Nature Reviews Endocrinology, Published online: 20 August 2026; doi:10.1038/s41574-026-01296-zHypochondroplasia is a rare genetic condition resulting in disproportionate short stature and relative macrocephaly. Owing to its phenotypic variability and often subtle presentation, diagnosis of hypochondroplasia can often be delayed. This Consensus Statement provides expert-led recommendations for the diagnosis of hypochondroplasia through a combination of clinical, radiological and genetic approaches.

Nature Reviews Gastroenterology & Hepatology, Published online: 03 September 2026; doi:10.1038/s41575-026-01242-4Major advances have deepened our understanding of intestinal stem (ISC) biology, yet the clinical translation remains limited, despite the promise of harnessing ISCs for both mucosal repair and regenerating functioning intestinal tissue. This Roadmap outlines progress, challenges and opportunities in the translation of ISC research to clinical therapy.

Nature Reviews Gastroenterology & Hepatology, Published online: 01 September 2026; doi:10.1038/s41575-026-01243-3Long non-coding RNAs (lncRNAs) are emerging as key regulators in cancer progression, including colorectal cancer (CRC). This Review provides a mechanistic overview of the role of lncRNAs in the CRC microenvironment and discusses their potential in precision oncology.

Nature Reviews Gastroenterology & Hepatology, Published online: 26 August 2026; doi:10.1038/s41575-026-01252-2Reply to ‘Closing the policy gap: including children in the global agenda for steatotic liver disease’

Nature Reviews Gastroenterology & Hepatology, Published online: 24 August 2026; doi:10.1038/s41575-026-01246-0Noncommunicable diseases kill 43 million people worldwide yearly, but one of their key biological drivers, the disruption of the gut microbiome by modifiable environmental factors, is still underappreciated by health stakeholders. The translation of microbiome science into concrete actions, from food safety regulators to public health authorities and policymakers, is urgently needed.

Nature Reviews Nephrology, Published online: 07 September 2026; doi:10.1038/s41581-026-01124-7Kidney disease is a growing global health challenge, yet research remains fragmented and under-resourced. To realize advances from emerging technologies, kidney research must become more collaborative, data-driven and interdisciplinary. A connected ecosystem from discovery to implementation with equity at its core is essential to translate scientific opportunity into kidney health impact.

Nature Reviews Nephrology, Published online: 01 September 2026; doi:10.1038/s41581-026-01120-xNucleic acid sensing is emerging as an important contributor to inflammation and tissue injury in the kidney. Here, the authors provide an overview of key DNA and RNA sensors, discuss evidence of their involvement in kidney pathology and consider the potential of these pathways as therapeutic targets.

Nature Reviews Nephrology, Published online: 25 August 2026; doi:10.1038/s41581-026-01121-wCreatine supplementation is unlikely to harm healthy kidneys, but a normal estimated glomerular filtration rate does not guarantee low risk. Adolescents and young adults with reduced nephron endowment, previous kidney disease or additional nephrotoxic exposures require targeted assessment and pragmatic harm reduction, including avoidance of loading and excessive protein intake.

Nature Reviews Nephrology, Published online: 18 August 2026; doi:10.1038/s41581-026-01118-5People with advanced kidney disease manage a heavy symptom burden in addition to the emotional, mental and social toll of chronic illness and kidney replacement therapy. Addressing misconceptions surrounding palliative care in nephrology might increase incorporation of palliative approaches, thereby improving symptom management and quality of life.

Nature Reviews Neurology, Published online: 07 September 2026; doi:10.1038/s41582-026-01263-2Cortical lesions are now recognized as a central component of multiple sclerosis pathophysiology. This Review summarizes the neuropathological and radiological evidence linking cortical pathology to disease mechanisms and assesses their diagnostic, prognostic and therapeutic relevance.

Nature Reviews Neurology, Published online: 01 September 2026; doi:10.1038/s41582-026-01251-6Obesity is emerging as a key risk factor for cognitive impairment and dementia. This article reviews the global epidemiology of obesity and highlights its pathophysiological effects on the brain. In addition, the authors consider obesity-related interventions that might improve cognitive function, including bariatric surgery and GLP-1 receptor agonists.

Nature Reviews Neurology, Published online: 27 August 2026; doi:10.1038/s41582-026-01265-0A new study shows that tau promotes mitochondrial reverse electron transport in a phosphorylation-dependent manner, thereby providing a mechanistic link between tau pathology and mitochondrial dysfunction.

Nature Reviews Neurology, Published online: 11 August 2026; doi:10.1038/s41582-026-01257-0A common mechanism of mutagenesis contributes to amyotrophic lateral sclerosis, frontotemporal dementia and Alzheimer disease, new research has shown.

Nature Reviews Rheumatology, Published online: 07 September 2026; doi:10.1038/s41584-026-01428-9New research suggests that tissue-resident macrophages occupy a fibrin-rich niche and actively remodel the synovial lining in rheumatoid arthritis, providing insights into the mechanisms underlying pannus formation and joint destruction.

Nature Reviews Rheumatology, Published online: 03 September 2026; doi:10.1038/s41584-026-01434-xIntracellular succinate promotes inflammatory macrophage responses through mitochondrial GPR91 signalling, linking metabolic dysregulation to macrophage-driven inflammation in rheumatoid arthritis.

Nature Reviews Rheumatology, Published online: 02 September 2026; doi:10.1038/s41584-026-01433-yThree studies report novel variants that promote autoinflammatory disease by enhancing CDC42–pyrin interactions leading to inflammasome activation.

Nature Reviews Rheumatology, Published online: 01 September 2026; doi:10.1038/s41584-026-01429-8Clinical trials in Sjögren disease have evolved from broad enrolment strategies to enriched populations with active systemic disease, which has facilitated important therapeutic breakthroughs. However, many patients remain outside therapeutic development programmes. Patient stratification and improved outcome assessment now offer an opportunity to develop precision trials across the disease spectrum.

Nature Reviews Urology, Published online: 02 September 2026; doi:10.1038/s41585-026-01182-3Despite growing clinical use of puberty suppression in transgender and gender-diverse adolescents, evidence on its effects on sexual development and well-being remains limited. Drawing on a targeted literature review, multidisciplinary expert opinion and a round table discussion at the 2025 European Professional Association for Transgender Health Conference, this Expert Recommendation emphasizes age-appropriate education, psychosocial support, individualized fertility and treatment decisions, positive discussions about sexuality, and the need for long-term interdisciplinary research and improved assessment tools.

Nature Reviews Urology, Published online: 18 August 2026; doi:10.1038/s41585-026-01184-1Chemotherapy-induced tumour pyroptosis affects distal haematopoiesis to elevate NLR

Nature Reviews Urology, Published online: 05 August 2026; doi:10.1038/s41585-026-01179-yIn this Consensus Statement, the International Bladder Cancer Group provides practical guidance on the use of biomarkers in bladder cancer, highlighting validated applications and important limitations across disease stages. The group also defined research priorities to support the prospective validation, standardization and clinical implementation of biomarkers.

Nature Reviews Urology, Published online: 03 August 2026; doi:10.1038/s41585-026-01181-4The US military’s proposal for routine testosterone screening presents a unique opportunity to improve men’s health. However, translating policy into practice will require evidence-based screening, accurate diagnosis, appropriate patient selection and careful consideration of fertility, lifestyle factors and long-term monitoring.