Nature Reviews Cardiology, Published online: 15 November 2024; doi:10.1038/s41569-024-01098-8Cell therapy has emerged in the past 20 years as a promising avenue for cardiac repair and regeneration. In this Review, Zhang and colleagues provide an overview of the evolution of cell-based and cell product-based therapies for the treatment of heart failure, including challenges and lessons learned, and summarize ongoing clinical trials on the feasibility of novel or underexplored treatment protocols.

Nature Reviews Cardiology, Published online: 14 November 2024; doi:10.1038/s41569-024-01099-7Debate exists regarding the best terminology for common presentations of heart diseases caused by epicardial and/or microvascular coronary artery disease with or without myocardial ischaemia. In this Comment, we discuss the pros and cons of a new proposal to replace the vessel-based nomenclature of acute and chronic coronary syndromes with the myocardial-oriented nomenclature of acute and non-acute myocardial ischaemic syndromes.

Nature Reviews Cardiology, Published online: 13 November 2024; doi:10.1038/s41569-024-01097-9In this Review on cardiodermatology, Gelfand and colleagues discuss specific skin findings associated with cardiovascular diseases, important cutaneous adverse effects of common cardiovascular therapies, and the effects of dermatological diseases and dermatological treatment on cardiovascular risk.

Nature Reviews Cardiology, Published online: 05 November 2024; doi:10.1038/s41569-024-01094-yIn this Review, Tao and colleagues discuss the design and applications of nanoparticles and nanofabricated biomaterials, such as hydrogels, external graft support devices and cell-based therapies, for the treatment of vein graft disease and highlight the potential of using these nanofabricated biomaterials alongside bypass surgery to improve local delivery efficiency and therapeutic efficacy.

Nature Reviews Clinical Oncology, Published online: 15 November 2024; doi:10.1038/s41571-024-00959-ySeveral chimeric antigen receptor (CAR) T cell therapies are approved for the treatment of various haematological cancers; however, they are all autologous products requiring individualized manufacturing for each patient, which presents technical, logistical and resource challenges that limits scalability and implementation, and even raises certain ethical questions. Allogeneic products have the potential to address many of these issues, but come with their own challenges. This Review summarizes the advantages and disadvantages of allogeneic CAR cell products derived from T cells or other immune cells, their engineering and progress towards clinical implementation, as well as hurdles that remain to be overcome.

Nature Reviews Clinical Oncology, Published online: 06 November 2024; doi:10.1038/s41571-024-00963-2The DESTINY-Breast06 trial investigated earlier and broader use of trastuzumab deruxtecan in patients with metastatic hormone-receptor-positive breast cancer, and demonstrated improvements in progression-free survival over standard chemotherapy. These data provide a meaningful advance; however, this strategy might not be right for all patients, and careful consideration is recommended before blanket use.

Nature Reviews Clinical Oncology, Published online: 01 November 2024; doi:10.1038/s41571-024-00956-1In several B cell malignancies, BTK is a crucial mediator of oncogenic signalling pathways and inhibitors of this kinase have substantially improved patient outcomes. This Review discusses the currently approved indications for covalent and non-covalent BTK inhibitors, as well as mechanisms of resistance, and novel BTK-targeted agents and treatment strategies that have the potential to further improve outcomes.

Nature Reviews Clinical Oncology, Published online: 25 October 2024; doi:10.1038/s41571-024-00962-3Cadonilimab is effective and safe in recurrent cervical cancer

Nature Reviews Endocrinology, Published online: 13 November 2024; doi:10.1038/s41574-024-01052-1Growth hormone-releasing hormone (GHRH) signalling modulation has shown beneficial effects in a wide range of diseases in preclinical research. This Review discusses the progression of research into the effects of GHRH agonist and antagonist treatment in several contexts, including cancer, inflammation, cardiovascular disease and metabolism.

Nature Reviews Endocrinology, Published online: 08 November 2024; doi:10.1038/s41574-024-01062-zMacrophages support pancreatic development

Nature Reviews Endocrinology, Published online: 08 November 2024; doi:10.1038/s41574-024-01063-yIL-17 has a role in whole-body homeostasis

Nature Reviews Endocrinology, Published online: 04 November 2024; doi:10.1038/s41574-024-01045-0This Review outlines the screening, enrolment and recruitment challenges in the TEDDY (The Environmental Determinants of Diabetes in the Young) study. The key findings related to the first primary end point are discussed, and future directions of study are highlighted.

Nature Reviews Gastroenterology & Hepatology, Published online: 11 November 2024; doi:10.1038/s41575-024-01014-yThe year 2024 was momentous for metabolic dysfunction-associated steatotic liver disease (MASLD): the approval of the first medication for treatment of at-risk metabolic dysfunction-associated steatohepatitis, updated guidelines on the screening, diagnosis and treatment of MASLD, and liver stiffness measurement as an important surrogate marker for liver-related outcomes in MASLD.

Nature Reviews Gastroenterology & Hepatology, Published online: 04 November 2024; doi:10.1038/s41575-024-01009-9Probiotics might prevent some necrotizing enterocolitis, late-onset sepsis and mortality in preterm infants. However, clinical practice varies widely, and families are often excluded from shared decision making. This Clinical Outlook highlights current evidence, clinical practice guidelines and the future outlook of probiotics in the neonatal intensive care unit.

Nature Reviews Gastroenterology & Hepatology, Published online: 31 October 2024; doi:10.1038/s41575-024-01003-1Cirrhosis morbidity and mortality are rising worldwide, with health disparities affecting minorities, people of low socioeconomic status, and underserved rural communities. This Review addresses inequities in cirrhosis management and liver transplantation, highlighting the immediate necessity for improving health equity.

Nature Reviews Gastroenterology & Hepatology, Published online: 29 October 2024; doi:10.1038/s41575-024-01016-wIntestinal tuft cells can act as injury-resistant stem cells

Nature Reviews Nephrology, Published online: 15 November 2024; doi:10.1038/s41581-024-00902-5Collagens are ubiquitously expressed and have been linked to a broad spectrum of disorders. Here, the authors discuss collagen subtypes and provide a summary of collagen disorders, fibrotic process and therapies, with an emphasis on kidney diseases.

Nature Reviews Nephrology, Published online: 22 October 2024; doi:10.1038/s41581-024-00904-3Treating AAV by targeting T cell responses

Nature Reviews Nephrology, Published online: 22 October 2024; doi:10.1038/s41581-024-00897-zCongenital nephrogenic diabetes insipidus is a rare but potentially life-threatening condition. This Consensus Statement provides clinical practice recommendations developed by the European Reference Network on Rare Kidney Diseases, the European Society for Paediatric Nephrology and patient advocates to support clinicians in the diagnosis, treatment and genetic counselling of children and adults with nephrogenic diabetes insipidus.

Nature Reviews Neurology, Published online: 15 November 2024; doi:10.1038/s41582-024-01035-wEffective treatments for the acute stages of intracerebral haemorrhage are currently limited. In this Review, the authors consider advances in therapeutic strategies and neurosurgical procedures, including acute care bundles, that promise a new era of interventions.

Nature Reviews Neurology, Published online: 13 November 2024; doi:10.1038/s41582-024-01039-6Dementia risk scores in diverse populations

Nature Reviews Neurology, Published online: 13 November 2024; doi:10.1038/s41582-024-01044-9Sex differences in Alzheimer disease could be influenced by differences in immune responses, new research suggests.

Nature Reviews Neurology, Published online: 04 November 2024; doi:10.1038/s41582-024-01034-xParkinson disease (PD) poses substantial management challenges owing to progressive disability and emergence of levodopa-resistant symptoms and treatment-related complications. This Review examines the current state of research into symptomatic and disease-modifying PD therapies and outlines future priorities for advancing our understanding and treatment of the disease.

Nature Reviews Rheumatology, Published online: 13 November 2024; doi:10.1038/s41584-024-01193-7Publisher Correction: Recent advances in the diagnosis and management of neuropsychiatric lupus

Nature Reviews Rheumatology, Published online: 06 November 2024; doi:10.1038/s41584-024-01181-xThis Review provides an overview of the pathogenesis, classification and diagnosis of and treatment strategies for adult and paediatric rheumatology patients with uveitis. The authors highlight the importance of collaborations between ophthalmologists and rheumatologists to provide optimal treatment of uveitis, improve patient care and enhance future research.

Nature Reviews Rheumatology, Published online: 04 November 2024; doi:10.1038/s41584-024-01187-5The presence of anti-IFI16 autoantibodies in patients with idiopathic interstitial pneumonia is linked to poor prognosis and could inform treatment.

Nature Reviews Rheumatology, Published online: 31 October 2024; doi:10.1038/s41584-024-01177-7Digital health has the potential to improve patient care in rheumatology and alleviate strain on the health-care system. This Review explores the current status of the transition from traditional health care to a model that harnesses the potential of digital health technologies, including discussion of the main benefits and barriers.

Nature Reviews Urology, Published online: 14 November 2024; doi:10.1038/s41585-024-00961-0The circadian rhythm has a crucial role in regulating nocturia. In this Review, the authors discuss how the brain–kidney–bladder circadian axis can lead to nocturia, prompted by the rationale that understanding these disruptions can lead to developing effective treatments targeting circadian rhythms.

Nature Reviews Urology, Published online: 14 November 2024; doi:10.1038/s41585-024-00953-0A common germline missense-encoding polymorphism in HSD3B1, called the adrenal-permissive allele, facilitates androgen synthesis from adrenal precursors via increased 3β-hydroxysteroid dehydrogenase 1 (3βHSD1). Here, the authors focus on mechanistic and clinical investigations of 3βHSD1 and the clinical consequences and potential utility of detecting adrenal-permissive allele inheritance.

Nature Reviews Urology, Published online: 11 November 2024; doi:10.1038/s41585-024-00970-z177Lu-PSMA-617 extends progression-free survival in taxane-naive mCRPC

Nature Reviews Urology, Published online: 11 November 2024; doi:10.1038/s41585-024-00972-xThe urge to advance: ICS 2024 drives innovation in continence care