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EKM Einführung in die klinische Medizin
GTE Historische Entwicklung der Medizin
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Aktuelle Forschungsergebnisse aus verschiedenen Gebieten der Humanmedizin
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Kardiologie
AUG
07
Stroke triggers an innate immune memory that drives cardiac dysfunction
By:
Irene Fernández-Ruiz
on
AUG
07
Nature Reviews Cardiology, Published online: 07 August 2024; doi:10.1038/s41569-024-01069-zAcute ischaemic stroke induces persistent innate immune memory through epigenetic changes in myeloid progenitors in the bone marrow, and this innate immune training contributes to cardiac remodelling and dysfunction in the long term, according to a new study.
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AUG
07
Mechanisms and treatment of pulmonary arterial hypertension
By:
Hossein-Ardeschir Ghofrani
on
AUG
07
Nature Reviews Cardiology, Published online: 07 August 2024; doi:10.1038/s41569-024-01064-4In this Review, Ghofrani and colleagues discuss the mechanisms underlying the development of pulmonary arterial hypertension, provide an overview of approved therapies and describe the predominantly non-vasodilatory drugs that are currently being tested in clinical trials.
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JUL
29
Potential new therapeutic target for HFpEF
By:
Irene Fernández-Ruiz
on
JUL
29
Nature Reviews Cardiology, Published online: 29 July 2024; doi:10.1038/s41569-024-01066-2A new small-molecule inhibitor of vasohibins reduces myocardial stiffness and improves diastolic relaxation in a rat model of HFpEF.
Mehr lesen >>
JUL
25
Epidemiology of cardiometabolic health in Latin America and strategies to address disparities
By:
Luisa C. C. Brant
on
JUL
25
Nature Reviews Cardiology, Published online: 25 July 2024; doi:10.1038/s41569-024-01058-2Cardiovascular diseases are the leading cause of death in Latin America and the Caribbean (LAC), precipitated by the unique milieu of population growth, rapid urbanization, socioeconomic disparities and prevalent cardiometabolic risk factors. Brant and colleagues summarize trends in cardiometabolic health in LAC and discuss tailored, innovative solutions to address the growing burden of disease in the region.
Mehr lesen >>
JUL
24
Reactive oxygen species in hypertension
By:
Livia L. Camargo
on
JUL
24
Nature Reviews Cardiology, Published online: 24 July 2024; doi:10.1038/s41569-024-01062-6In this Review, Touyz and colleagues discuss the role of reactive oxygen species in the pathophysiology of hypertension, focusing on the mechanisms of reactive oxygen species generation and oxidative stress in hypertension, as well as the alterations in redox signalling. They also discuss potential therapeutic strategies for targeting oxidative stress in hypertension.
Mehr lesen >>
JUL
22
Cardiac sarcomere turnover by unidirectional replacement of proteins
By:
Gregory B. Lim
on
JUL
22
Nature Reviews Cardiology, Published online: 22 July 2024; doi:10.1038/s41569-024-01065-3A new study indicates that proteins in the sarcomere complex are stochastically removed and degraded and are replaced by newly translated proteins. Sarcomere turnover occurs at a similar rate within cardiomyocytes and across the heart and slows with ageing.
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JUL
22
Standardization and clinical applications of retinal imaging biomarkers for cardiovascular disease: a Roadmap from an NHLBI workshop
By:
Emily Y. Chew
on
JUL
22
Nature Reviews Cardiology, Published online: 22 July 2024; doi:10.1038/s41569-024-01060-8In this Roadmap arising from an NHLBI workshop, Chew and colleagues explore the use of retinal imaging biomarkers for the prediction, diagnosis and monitoring of systemic cardiovascular diseases. The authors identify knowledge gaps and research opportunities to translate retinal imaging biomarkers into clinical practice.
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JUL
19
Functional control of myosin motors in the cardiac cycle
By:
Malcolm Irving
on
JUL
19
Nature Reviews Cardiology, Published online: 19 July 2024; doi:10.1038/s41569-024-01063-5Contraction of the heart is driven by cyclical interactions between myosin and actin filaments driven by ATP hydrolysis. In this Review, Irving summarizes the basal cardiac cycle of the healthy human heart at the ventricular, cellular, sarcomeric, and molecular levels and the implications for the development of novel therapies for heart disease.
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Weitere Beiträge
Klinische Onkologie
AUG
19
The MARIPOSA trials — implications for the treatment of
EGFR
-mutant NSCLC
By:
Fatemeh Ardeshir-Larijani
on
AUG
19
Nature Reviews Clinical Oncology, Published online: 19 August 2024; doi:10.1038/s41571-024-00938-3In the past 2 years, substantial improvements have been made in the management of advanced-stage EGFR-mutant non-small-cell lung cancer. Recent studies have suggested added benefit from the combination of third-generation tyrosine-kinase inhibitors with either chemotherapy or a bispecific antibody targeting EGFR and MET. Herein, we summarize these advances and their implications for clinical practice.
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AUG
19
Applications of cell therapy in the treatment of virus-associated cancers
By:
Keri Toner
on
AUG
19
Nature Reviews Clinical Oncology, Published online: 19 August 2024; doi:10.1038/s41571-024-00930-xSeveral different viruses have a role in cancer pathogenesis, contributing to the development of various haematological malignancies and solid tumours via diverse, multifaceted mechanisms. However, this viral aetiology presents a unique opportunity for adoptive virus-specific T cell (VST) therapy. This Review summarizes the mechanisms of viral carcinogenesis and describes the current clinical experience with adoptive cellular immunotherapies for virus-related cancers, predominantly using non-genetically modified VSTs. The authors also discuss challenges and future directions for the ongoing clinical development of VST therapies.
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AUG
12
Blinatumomab improves outcomes in adult MRD-negative BCP-ALL
By:
Diana Romero
on
AUG
12
Nature Reviews Clinical Oncology, Published online: 12 August 2024; doi:10.1038/s41571-024-00936-5Blinatumomab improves outcomes in adult MRD-negative BCP-ALL
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AUG
02
Author Correction: Management of patients with advanced-stage HER2-positive breast cancer: current evidence and future perspectives
By:
Antonio Marra
on
AUG
02
Nature Reviews Clinical Oncology, Published online: 02 August 2024; doi:10.1038/s41571-024-00933-8Author Correction: Management of patients with advanced-stage HER2-positive breast cancer: current evidence and future perspectives
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JUL
29
Anlotinib plus benmelstobart and chemotherapy are effective in ES-SCLC
By:
Diana Romero
on
JUL
29
Nature Reviews Clinical Oncology, Published online: 29 July 2024; doi:10.1038/s41571-024-00931-wAnlotinib plus benmelstobart and chemotherapy are effective in ES-SCLC
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JUL
23
Spatial landscapes of cancers: insights and opportunities
By:
Julia Chen
on
JUL
23
Nature Reviews Clinical Oncology, Published online: 23 July 2024; doi:10.1038/s41571-024-00926-7Solid tumours are complex ecosystems comprising many different cell types with spatially structured arrangement. The authors of the Review describe how single-cell and spatial profiling tools have been applied to understand the cellular architecture of the tumour microenvironment. These approaches have potential to improve the way cancer is diagnosed and treated.
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JUL
22
BrECADD raises the bar in classical Hodgkin lymphoma
By:
David Killock
on
JUL
22
Nature Reviews Clinical Oncology, Published online: 22 July 2024; doi:10.1038/s41571-024-00928-5BrECADD raises the bar in classical Hodgkin lymphoma
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JUL
22
Tisotumab vedotin effective in recurrent cervical cancer
By:
Peter Sidaway
on
JUL
22
Nature Reviews Clinical Oncology, Published online: 22 July 2024; doi:10.1038/s41571-024-00929-4Tisotumab vedotin effective in recurrent cervical cancer
Mehr lesen >>
Weitere Beiträge
Endokrinologie
AUG
22
New insights into the regulation of GIPR signalling
By:
Yusman Manchanda
on
AUG
22
Nature Reviews Endocrinology, Published online: 22 August 2024; doi:10.1038/s41574-024-01027-2Two recent studies have unravelled novel modes of glucose-dependent insulinotropic polypeptide receptor (GIPR) signalling regulation. Kizilkaya et al. characterized the effect of changes in β-arrestin 2 coupling with naturally occurring GIPR coding variants, whereas Regmi et al. investigated GIPR expression profiles and functional regulation in adipocytes.
Mehr lesen >>
AUG
16
Thyroid nodules: diagnosis and management
By:
Giorgio Grani
on
AUG
16
Nature Reviews Endocrinology, Published online: 16 August 2024; doi:10.1038/s41574-024-01025-4Thyroid nodules are common; the majority are benign and asymptomatic, and therefore the main aim of the diagnostic process is to determine their clinical significance without leading to overdiagnosis and, consequently, overtreatment, as outlined in this article.
Mehr lesen >>
AUG
15
International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents
By:
Ruth T. Casey
on
AUG
15
Nature Reviews Endocrinology, Published online: 15 August 2024; doi:10.1038/s41574-024-01024-5Phaeochromocytomas and paragangliomas (PPGL) are rare endocrine tumours that can affect paediatric patients as well as adults. In this first international Consensus Statement on PPGL in paediatric patients, the authors discuss the diagnosis, management and long-term surveillance of these tumours in children and adolescents.
Mehr lesen >>
AUG
13
Microbial hydrogen sulfide hampers L-cell GLP-1 production
By:
Senegal Carty
on
AUG
13
Nature Reviews Endocrinology, Published online: 13 August 2024; doi:10.1038/s41574-024-01028-1Microbial hydrogen sulfide hampers L-cell GLP-1 production
Mehr lesen >>
AUG
13
Medically not yet explained symptoms in hypothyroidism
By:
Laszlo Hegedüs
on
AUG
13
Nature Reviews Endocrinology, Published online: 13 August 2024; doi:10.1038/s41574-024-01022-7Medically not yet explained symptoms (MNYES) are an important consideration in patients treated for hypothyroidism who experience persistent symptoms. This Perspective brings attention to the issue of MNYES in hypothyroidism and considers effective management.
Mehr lesen >>
AUG
02
Combination therapy increases human β-cell mass in vivo
By:
Olivia Tysoe
on
AUG
02
Nature Reviews Endocrinology, Published online: 02 August 2024; doi:10.1038/s41574-024-01026-3Combination therapy increases human β-cell mass in vivo
Mehr lesen >>
JUL
30
Endocrine effects of heat exposure and relevance to climate change
By:
Fadil M. Hannan
on
JUL
30
Nature Reviews Endocrinology, Published online: 30 July 2024; doi:10.1038/s41574-024-01017-4Climate change is causing human populations to be exposed to increasingly higher ambient temperatures and more frequent and extreme heatwaves than previously observed. This Perspective considers the available evidence on the endocrine effects of heat exposure, and maps out a path for future research into this field.
Mehr lesen >>
JUL
25
The interactions between energy homeostasis and neurovascular plasticity
By:
Bandy Chen
on
JUL
25
Nature Reviews Endocrinology, Published online: 25 July 2024; doi:10.1038/s41574-024-01021-8Nutritional imbalances (such as overnutrition in obesity) alter many properties of the neurovascular system, including neurovascular coupling and blood–brain barrier permeability. This Perspective examines how lifestyle interventions targeting weight loss, including intermittent fasting, caloric restriction and physical activity, affect the neurovascular system and neuronal networks.
Mehr lesen >>
Weitere Beiträge
AUG
22
New insights into the regulation of GIPR signalling
By:
Yusman Manchanda
on
AUG
22
Nature Reviews Endocrinology, Published online: 22 August 2024; doi:10.1038/s41574-024-01027-2Two recent studies have unravelled novel modes of glucose-dependent insulinotropic polypeptide receptor (GIPR) signalling regulation. Kizilkaya et al. characterized the effect of changes in β-arrestin 2 coupling with naturally occurring GIPR coding variants, whereas Regmi et al. investigated GIPR expression profiles and functional regulation in adipocytes.
Mehr lesen >>
AUG
16
Thyroid nodules: diagnosis and management
By:
Giorgio Grani
on
AUG
16
Nature Reviews Endocrinology, Published online: 16 August 2024; doi:10.1038/s41574-024-01025-4Thyroid nodules are common; the majority are benign and asymptomatic, and therefore the main aim of the diagnostic process is to determine their clinical significance without leading to overdiagnosis and, consequently, overtreatment, as outlined in this article.
Mehr lesen >>
AUG
15
International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents
By:
Ruth T. Casey
on
AUG
15
Nature Reviews Endocrinology, Published online: 15 August 2024; doi:10.1038/s41574-024-01024-5Phaeochromocytomas and paragangliomas (PPGL) are rare endocrine tumours that can affect paediatric patients as well as adults. In this first international Consensus Statement on PPGL in paediatric patients, the authors discuss the diagnosis, management and long-term surveillance of these tumours in children and adolescents.
Mehr lesen >>
AUG
13
Microbial hydrogen sulfide hampers L-cell GLP-1 production
By:
Senegal Carty
on
AUG
13
Nature Reviews Endocrinology, Published online: 13 August 2024; doi:10.1038/s41574-024-01028-1Microbial hydrogen sulfide hampers L-cell GLP-1 production
Mehr lesen >>
AUG
13
Medically not yet explained symptoms in hypothyroidism
By:
Laszlo Hegedüs
on
AUG
13
Nature Reviews Endocrinology, Published online: 13 August 2024; doi:10.1038/s41574-024-01022-7Medically not yet explained symptoms (MNYES) are an important consideration in patients treated for hypothyroidism who experience persistent symptoms. This Perspective brings attention to the issue of MNYES in hypothyroidism and considers effective management.
Mehr lesen >>
AUG
02
Combination therapy increases human β-cell mass in vivo
By:
Olivia Tysoe
on
AUG
02
Nature Reviews Endocrinology, Published online: 02 August 2024; doi:10.1038/s41574-024-01026-3Combination therapy increases human β-cell mass in vivo
Mehr lesen >>
JUL
30
Endocrine effects of heat exposure and relevance to climate change
By:
Fadil M. Hannan
on
JUL
30
Nature Reviews Endocrinology, Published online: 30 July 2024; doi:10.1038/s41574-024-01017-4Climate change is causing human populations to be exposed to increasingly higher ambient temperatures and more frequent and extreme heatwaves than previously observed. This Perspective considers the available evidence on the endocrine effects of heat exposure, and maps out a path for future research into this field.
Mehr lesen >>
JUL
25
The interactions between energy homeostasis and neurovascular plasticity
By:
Bandy Chen
on
JUL
25
Nature Reviews Endocrinology, Published online: 25 July 2024; doi:10.1038/s41574-024-01021-8Nutritional imbalances (such as overnutrition in obesity) alter many properties of the neurovascular system, including neurovascular coupling and blood–brain barrier permeability. This Perspective examines how lifestyle interventions targeting weight loss, including intermittent fasting, caloric restriction and physical activity, affect the neurovascular system and neuronal networks.
Mehr lesen >>
Weitere Beiträge
GI und Hepatologie
AUG
22
Mapping neuroimmune interactions in the gut
By:
Katrina Ray
on
AUG
22
Nature Reviews Gastroenterology & Hepatology, Published online: 22 August 2024; doi:10.1038/s41575-024-00982-5Mapping neuroimmune interactions in the gut
Mehr lesen >>
AUG
15
Liver diseases and hepatocellular carcinoma in the Asia-Pacific region: burden, trends, challenges and future directions
By:
Lung-Yi Mak
on
AUG
15
Nature Reviews Gastroenterology & Hepatology, Published online: 15 August 2024; doi:10.1038/s41575-024-00967-4Mortality related to liver diseases and liver cancer is high and on the rise in the Asia-Pacific region. This Review summarizes the current epidemiological data and discusses the changing landscape of burden and aetiology of liver disease and liver cancer in the Asia-Pacific region.
Mehr lesen >>
AUG
12
EPC 2024
By:
Jordan Hindson
on
AUG
12
Nature Reviews Gastroenterology & Hepatology, Published online: 12 August 2024; doi:10.1038/s41575-024-00979-0EPC 2024
Mehr lesen >>
AUG
08
Cellular and molecular basis of proximal small intestine disorders
By:
Tania Bildstein
on
AUG
08
Nature Reviews Gastroenterology & Hepatology, Published online: 08 August 2024; doi:10.1038/s41575-024-00962-9The proximal small intestine is key for nutrition, metabolism and immune responses, and can be affected by a wide range of disorders. This Review describes the cellular and molecular bases of diseases of the proximal small intestine (including rare monogenic disorders), proposing a mechanism-based taxonomy.
Mehr lesen >>
AUG
05
Risankizumab versus ustekinumab for Crohn’s disease: a phase IIIb study
By:
Eleni Kotsiliti
on
AUG
05
Nature Reviews Gastroenterology & Hepatology, Published online: 05 August 2024; doi:10.1038/s41575-024-00973-6Risankizumab versus ustekinumab for Crohn’s disease: a phase IIIb study
Mehr lesen >>
AUG
05
EASL Congress 2024
By:
Eleni Kotsiliti
on
AUG
05
Nature Reviews Gastroenterology & Hepatology, Published online: 05 August 2024; doi:10.1038/s41575-024-00971-8EASL Congress 2024
Mehr lesen >>
AUG
05
Metastatic pancreatic cancer and the liver
By:
Eleni Kotsiliti
on
AUG
05
Nature Reviews Gastroenterology & Hepatology, Published online: 05 August 2024; doi:10.1038/s41575-024-00972-7Metastatic pancreatic cancer and the liver
Mehr lesen >>
AUG
05
Author Correction: A roadmap for clinical trials in MASH-related compensated cirrhosis
By:
Juan M. Pericàs
on
AUG
05
Nature Reviews Gastroenterology & Hepatology, Published online: 05 August 2024; doi:10.1038/s41575-024-00976-3Author Correction: A roadmap for clinical trials in MASH-related compensated cirrhosis
Mehr lesen >>
Weitere Beiträge
AUG
22
Mapping neuroimmune interactions in the gut
By:
Katrina Ray
on
AUG
22
Nature Reviews Gastroenterology & Hepatology, Published online: 22 August 2024; doi:10.1038/s41575-024-00982-5Mapping neuroimmune interactions in the gut
Mehr lesen >>
AUG
15
Liver diseases and hepatocellular carcinoma in the Asia-Pacific region: burden, trends, challenges and future directions
By:
Lung-Yi Mak
on
AUG
15
Nature Reviews Gastroenterology & Hepatology, Published online: 15 August 2024; doi:10.1038/s41575-024-00967-4Mortality related to liver diseases and liver cancer is high and on the rise in the Asia-Pacific region. This Review summarizes the current epidemiological data and discusses the changing landscape of burden and aetiology of liver disease and liver cancer in the Asia-Pacific region.
Mehr lesen >>
AUG
12
EPC 2024
By:
Jordan Hindson
on
AUG
12
Nature Reviews Gastroenterology & Hepatology, Published online: 12 August 2024; doi:10.1038/s41575-024-00979-0EPC 2024
Mehr lesen >>
AUG
08
Cellular and molecular basis of proximal small intestine disorders
By:
Tania Bildstein
on
AUG
08
Nature Reviews Gastroenterology & Hepatology, Published online: 08 August 2024; doi:10.1038/s41575-024-00962-9The proximal small intestine is key for nutrition, metabolism and immune responses, and can be affected by a wide range of disorders. This Review describes the cellular and molecular bases of diseases of the proximal small intestine (including rare monogenic disorders), proposing a mechanism-based taxonomy.
Mehr lesen >>
AUG
05
Risankizumab versus ustekinumab for Crohn’s disease: a phase IIIb study
By:
Eleni Kotsiliti
on
AUG
05
Nature Reviews Gastroenterology & Hepatology, Published online: 05 August 2024; doi:10.1038/s41575-024-00973-6Risankizumab versus ustekinumab for Crohn’s disease: a phase IIIb study
Mehr lesen >>
AUG
05
EASL Congress 2024
By:
Eleni Kotsiliti
on
AUG
05
Nature Reviews Gastroenterology & Hepatology, Published online: 05 August 2024; doi:10.1038/s41575-024-00971-8EASL Congress 2024
Mehr lesen >>
AUG
05
Metastatic pancreatic cancer and the liver
By:
Eleni Kotsiliti
on
AUG
05
Nature Reviews Gastroenterology & Hepatology, Published online: 05 August 2024; doi:10.1038/s41575-024-00972-7Metastatic pancreatic cancer and the liver
Mehr lesen >>
AUG
05
Author Correction: A roadmap for clinical trials in MASH-related compensated cirrhosis
By:
Juan M. Pericàs
on
AUG
05
Nature Reviews Gastroenterology & Hepatology, Published online: 05 August 2024; doi:10.1038/s41575-024-00976-3Author Correction: A roadmap for clinical trials in MASH-related compensated cirrhosis
Mehr lesen >>
Weitere Beiträge
Nephrologie
AUG
20
A focus on kidney ageing
By:
on
AUG
20
Nature Reviews Nephrology, Published online: 20 August 2024; doi:10.1038/s41581-024-00879-1Population ageing will exacerbate the burden of ageing-related diseases, including chronic kidney disease. Mitigating the effects of this burden will require coordinated, multinational efforts.
Mehr lesen >>
AUG
19
Advances in uromodulin biology and potential clinical applications
By:
Azuma Nanamatsu
on
AUG
19
Nature Reviews Nephrology, Published online: 19 August 2024; doi:10.1038/s41581-024-00881-7In this Review, the authors examine advances in uromodulin biology, including the existence of non-polymeric forms of the protein, its versatile functions, crosstalk with the immune system, its potential as a biomarker and its role in kidney disease, as well as considering how uromodulin might be targeted therapeutically.
Mehr lesen >>
AUG
13
Improving the quality of pharmacoepidemiological studies using the target trial emulation framework
By:
Emilie Lambourg
on
AUG
13
Nature Reviews Nephrology, Published online: 13 August 2024; doi:10.1038/s41581-024-00884-4Improving the quality of pharmacoepidemiological studies using the target trial emulation framework
Mehr lesen >>
AUG
07
From improbable to possible: pregnancy with advanced chronic kidney disease
By:
Alejandra Orozco-Guillén
on
AUG
07
Nature Reviews Nephrology, Published online: 07 August 2024; doi:10.1038/s41581-024-00882-6From improbable to possible: pregnancy with advanced chronic kidney disease
Mehr lesen >>
AUG
02
Lymphocytes and innate immune cells in acute kidney injury and repair
By:
Kyungho Lee
on
AUG
02
Nature Reviews Nephrology, Published online: 02 August 2024; doi:10.1038/s41581-024-00875-5Here, the authors describe the roles of lymphocytes and innate immune cells in inflammatory responses and repair processes during acute kidney injury (AKI). They also discuss the roles of immune cells in crosstalk pathways that result in AKI-induced distant organ dysfunction.
Mehr lesen >>
AUG
01
Making advance care planning easier for adults with kidney disease and their clinicians
By:
Ryan D. McMahan
on
AUG
01
Nature Reviews Nephrology, Published online: 01 August 2024; doi:10.1038/s41581-024-00871-9Advance care planning (ACP) has evolved from a narrow focus on end-of-life preference, such as resuscitation, to a continuum of care planning across the life course. Older adults with kidney disease have high morbidity and mortality, and easy-to-use tools can make ACP easier for patients and clinicians.
Mehr lesen >>
JUL
31
Drug repurposing for glomerular diseases: an underutilized resource
By:
Monica Suet Ying Ng
on
JUL
31
Nature Reviews Nephrology, Published online: 31 July 2024; doi:10.1038/s41581-024-00864-8Drug repurposing could expand the therapeutic options available to patients with glomerular disease. Here, the authors examine different approaches to the identification of drug candidates, consider current immunosuppressive and non-immunological options and discuss strategies to maximize drug repurposing in glomerular disease.
Mehr lesen >>
JUL
30
Anti-nephrin autoantibodies: a paradigm shift in podocytopathies
By:
Zhao Cui
on
JUL
30
Nature Reviews Nephrology, Published online: 30 July 2024; doi:10.1038/s41581-024-00873-7A new study demonstrates that anti-nephrin autoantibodies are not merely markers but also actively contribute to the pathogenesis of minimal change disease and primary focal segmental glomerulosclerosis. This insight not only provides a non-invasive diagnostic alternative to kidney biopsies, but also suggests potential for novel targeted therapies.
Mehr lesen >>
Weitere Beiträge
AUG
20
A focus on kidney ageing
By:
on
AUG
20
Nature Reviews Nephrology, Published online: 20 August 2024; doi:10.1038/s41581-024-00879-1Population ageing will exacerbate the burden of ageing-related diseases, including chronic kidney disease. Mitigating the effects of this burden will require coordinated, multinational efforts.
Mehr lesen >>
AUG
19
Advances in uromodulin biology and potential clinical applications
By:
Azuma Nanamatsu
on
AUG
19
Nature Reviews Nephrology, Published online: 19 August 2024; doi:10.1038/s41581-024-00881-7In this Review, the authors examine advances in uromodulin biology, including the existence of non-polymeric forms of the protein, its versatile functions, crosstalk with the immune system, its potential as a biomarker and its role in kidney disease, as well as considering how uromodulin might be targeted therapeutically.
Mehr lesen >>
AUG
13
Improving the quality of pharmacoepidemiological studies using the target trial emulation framework
By:
Emilie Lambourg
on
AUG
13
Nature Reviews Nephrology, Published online: 13 August 2024; doi:10.1038/s41581-024-00884-4Improving the quality of pharmacoepidemiological studies using the target trial emulation framework
Mehr lesen >>
AUG
07
From improbable to possible: pregnancy with advanced chronic kidney disease
By:
Alejandra Orozco-Guillén
on
AUG
07
Nature Reviews Nephrology, Published online: 07 August 2024; doi:10.1038/s41581-024-00882-6From improbable to possible: pregnancy with advanced chronic kidney disease
Mehr lesen >>
AUG
02
Lymphocytes and innate immune cells in acute kidney injury and repair
By:
Kyungho Lee
on
AUG
02
Nature Reviews Nephrology, Published online: 02 August 2024; doi:10.1038/s41581-024-00875-5Here, the authors describe the roles of lymphocytes and innate immune cells in inflammatory responses and repair processes during acute kidney injury (AKI). They also discuss the roles of immune cells in crosstalk pathways that result in AKI-induced distant organ dysfunction.
Mehr lesen >>
AUG
01
Making advance care planning easier for adults with kidney disease and their clinicians
By:
Ryan D. McMahan
on
AUG
01
Nature Reviews Nephrology, Published online: 01 August 2024; doi:10.1038/s41581-024-00871-9Advance care planning (ACP) has evolved from a narrow focus on end-of-life preference, such as resuscitation, to a continuum of care planning across the life course. Older adults with kidney disease have high morbidity and mortality, and easy-to-use tools can make ACP easier for patients and clinicians.
Mehr lesen >>
JUL
31
Drug repurposing for glomerular diseases: an underutilized resource
By:
Monica Suet Ying Ng
on
JUL
31
Nature Reviews Nephrology, Published online: 31 July 2024; doi:10.1038/s41581-024-00864-8Drug repurposing could expand the therapeutic options available to patients with glomerular disease. Here, the authors examine different approaches to the identification of drug candidates, consider current immunosuppressive and non-immunological options and discuss strategies to maximize drug repurposing in glomerular disease.
Mehr lesen >>
JUL
30
Anti-nephrin autoantibodies: a paradigm shift in podocytopathies
By:
Zhao Cui
on
JUL
30
Nature Reviews Nephrology, Published online: 30 July 2024; doi:10.1038/s41581-024-00873-7A new study demonstrates that anti-nephrin autoantibodies are not merely markers but also actively contribute to the pathogenesis of minimal change disease and primary focal segmental glomerulosclerosis. This insight not only provides a non-invasive diagnostic alternative to kidney biopsies, but also suggests potential for novel targeted therapies.
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Neurologie
AUG
19
Distinct active zone protein machineries mediate Ca
2+
channel clustering and vesicle priming at hippocampal synapses
By:
Javier Emperador-Melero
on
AUG
19
Nature Neuroscience, Published online: 19 August 2024; doi:10.1038/s41593-024-01720-5The active zone primes synaptic vesicles and clusters voltage-gated Ca2+ channels fast neurotransmitter release. Here the authors dissect the underlying molecular architecture and show that distinct protein machineries execute these functions.
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AUG
15
Publisher Correction: Nested compressed co-representations of multiple sequential experiences during sleep
By:
Kefei Liu
on
AUG
15
Nature Neuroscience, Published online: 15 August 2024; doi:10.1038/s41593-024-01751-yPublisher Correction: Nested compressed co-representations of multiple sequential experiences during sleep
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AUG
14
Author Correction: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
By:
Samira Parhizkar
on
AUG
14
Nature Neuroscience, Published online: 14 August 2024; doi:10.1038/s41593-024-01752-xAuthor Correction: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
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AUG
08
Neuronal activity stimulates a genetic program to rapidly generate synapses during development
By:
on
AUG
08
Nature Neuroscience, Published online: 08 August 2024; doi:10.1038/s41593-024-01729-wIn Caenorhabditis elegans, loss of the transcription factors FOS-1 and EGL-43 — orthologs of human FOS and MECOM, respectively — severely reduces presynaptic gene expression in dopaminergic neurons. These transcription factors form an activity-regulated positive feedback loop, which modulates the expression of synaptic genes and genetic programs to promote synapse formation.
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AUG
06
That’s a wrap
By:
Henrietta Howells
on
AUG
06
Nature Neuroscience, Published online: 06 August 2024; doi:10.1038/s41593-024-01733-0That’s a wrap
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AUG
06
Astrocytes know when to feed neurons
By:
George Andrew S. Inglis
on
AUG
06
Nature Neuroscience, Published online: 06 August 2024; doi:10.1038/s41593-024-01734-zAstrocytes know when to feed neurons
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AUG
06
Neutrophil–microglia interactions in AD
By:
Leonie Welberg
on
AUG
06
Nature Neuroscience, Published online: 06 August 2024; doi:10.1038/s41593-024-01732-1Neutrophil–microglia interactions in AD
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AUG
06
Glia move to the foreground
By:
on
AUG
06
Nature Neuroscience, Published online: 06 August 2024; doi:10.1038/s41593-024-01735-yIn this special issue of Nature Neuroscience, we shine a spotlight on glia. Research into glia has become one of the most exciting and dynamic subfields of neuroscience, yet there is still much to be discovered about the diverse forms and functions of these cells.
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AUG
22
Author Correction: Neurological care for LGBT+ people
By:
Salvatore Giovanni Volpe
on
AUG
22
Nature Reviews Neurology, Published online: 22 August 2024; doi:10.1038/s41582-024-01015-0Author Correction: Neurological care for LGBT+ people
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AUG
19
Insights from 25 years of onabotulinumtoxinA in migraine — mechanisms and management
By:
Patricia Pozo-Rosich
on
AUG
19
Nature Reviews Neurology, Published online: 19 August 2024; doi:10.1038/s41582-024-01002-5OnabotulinumtoxinA was first linked to beneficial effects in migraine 25 years ago and has since become a widely used treatment for chronic migraine. In this Review, Pozo-Rosich and colleagues consider the impact that onabotulinumtoxinA has had on the management of chronic migraine and on the research field.
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AUG
12
Antisense oligonucleotide shows potential in Charcot–Marie–Tooth disease
By:
Ian Fyfe
on
AUG
12
Nature Reviews Neurology, Published online: 12 August 2024; doi:10.1038/s41582-024-01013-2Antisense oligonucleotide treatment has therapeutic potential in a severe form of Charcot–Marie–Tooth disease, according to a new study.
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AUG
09
Peripheral nervous system immune-related adverse events due to checkpoint inhibition
By:
Meabh O’Hare
on
AUG
09
Nature Reviews Neurology, Published online: 09 August 2024; doi:10.1038/s41582-024-01001-6Some patients who are treated with checkpoint inhibitors experience peripheral nervous system (PNS) immune-related adverse events (irAEs). O’Hare and Guidon describe the spectrum of PNS irAE phenotypes, discuss their underlying mechanisms and outline a consensus-based, pathophysiology-driven approach to their clinical management.
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AUG
08
Disentangling clinical and biological trajectories of neurodegenerative diseases
By:
Nicolas Villain
on
AUG
08
Nature Reviews Neurology, Published online: 08 August 2024; doi:10.1038/s41582-024-01004-3In recent years, we have seen a shift towards defining sporadic neurodegenerative diseases as a biological continuum. Here, we discuss the risks associated with this shift, emphasize the importance of maintaining a strong connection between disease definitions and subsequent clinical outcomes, and suggest clinicobiological frameworks to disentangle multiple discrete nosological entities.
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AUG
07
Identifying and reducing risks of neurological complications associated with vaccination
By:
Lahiru Handunnetthi
on
AUG
07
Nature Reviews Neurology, Published online: 07 August 2024; doi:10.1038/s41582-024-01000-7Vaccination has transformed the global fight against infectious diseases and has a highly favourable benefit–risk profile in most people, although adverse events, including neurological complications, can occasionally occur. This article reviews the links between vaccination and neurological disease and considers the role of neurologists in identifying safety signals and managing risk.
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AUG
06
Single-cell atlas of Alzheimer disease vulnerability
By:
Lisa Kiani
on
AUG
06
Nature Reviews Neurology, Published online: 06 August 2024; doi:10.1038/s41582-024-01008-zSingle-cell atlas of Alzheimer disease vulnerability
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AUG
06
Shared glial pathology in HD and schizophrenia
By:
Lisa Kiani
on
AUG
06
Nature Reviews Neurology, Published online: 06 August 2024; doi:10.1038/s41582-024-01010-5Shared glial pathology in HD and schizophrenia
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Rheumatologie
AUG
22
Advancing equity in genomic medicine for rheumatology
By:
Roberto Díaz-Peña
on
AUG
22
Nature Reviews Rheumatology, Published online: 22 August 2024; doi:10.1038/s41584-024-01156-yIncreasing diversity in genomic studies is essential to advance precision medicine and health equity in rheumatic diseases. Addressing structural and logistical barriers to include underrepresented populations, particularly in Africa and Latin America, could improve our understanding of rheumatic diseases and lead to better healthcare outcomes for all.
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AUG
20
PDZK1 downregulation linked to mitochondrial dysfunction in OA
By:
Maria Papatriantafyllou
on
AUG
20
Nature Reviews Rheumatology, Published online: 20 August 2024; doi:10.1038/s41584-024-01157-xThe PDZ domain-containing scaffold protein PDZK1 is downregulated in osteoarthritic chondrocytes and is linked to mitochondrial dysfunction and chondrocyte senescence.
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AUG
09
Ion channels in osteoarthritis: emerging roles and potential targets
By:
Renpeng Zhou
on
AUG
09
Nature Reviews Rheumatology, Published online: 09 August 2024; doi:10.1038/s41584-024-01146-0Ion channels have key functions in chondrocytes, bone cells, immune cells and neurons. Liu and colleagues discuss how these functions might contribute to cartilage degeneration, bone formation inflammation and pain in osteoarthritis, and highlight the therapeutic potential of ion channel modulators.
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AUG
08
Behavioural therapy app for fibromyalgia
By:
Sarah Onuora
on
AUG
08
Nature Reviews Rheumatology, Published online: 08 August 2024; doi:10.1038/s41584-024-01151-3Behavioural therapy app for fibromyalgia
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AUG
07
The past 25 years in paediatric rheumatology: insights from monogenic diseases
By:
Seza Ozen
on
AUG
07
Nature Reviews Rheumatology, Published online: 07 August 2024; doi:10.1038/s41584-024-01145-1Paediatric rheumatology has seen many notable developments in the past 25 years, including the introduction of the concept of autoinflammation and a greater understanding of the genetics and pathogenesis of inflammatory diseases. In this Perspective, Ozen and Aksentijevich discuss how these and other discoveries have transformed the field and herald improvements in patient care.
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AUG
07
The role of obesity and adipose tissue dysfunction in osteoarthritis pain
By:
Marie Binvignat
on
AUG
07
Nature Reviews Rheumatology, Published online: 07 August 2024; doi:10.1038/s41584-024-01143-3In this Review, the authors explore the complex interactions between osteoarthritis-related pain and obesity, adipose tissue dysfunction and metabolic syndrome, and discuss how knowledge of these relationships could help improve pain management and identify new therapeutic options.
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AUG
06
Advancements and challenges in CAR T cell therapy in autoimmune diseases
By:
Georg Schett
on
AUG
06
Nature Reviews Rheumatology, Published online: 06 August 2024; doi:10.1038/s41584-024-01139-zCAR T cell therapy shows promise for achieving long-term drug-free remission in various autoimmune diseases. This Review discusses the ongoing challenges and unanswered questions of CAR T cell therapy in autoimmune diseases, including pre-procedural, procedural and post-procedural considerations.
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AUG
01
Shedding light onto the immunometabolic effects of glucocorticoids
By:
Luis M. Franco
on
AUG
01
Nature Reviews Rheumatology, Published online: 01 August 2024; doi:10.1038/s41584-024-01144-2Glucocorticoids are important anti-inflammatory and immunosuppressive drugs and potent regulators of metabolism. However, their immune and metabolic effects have been treated as separate entities. New research is shedding light onto the intersection between the immunoregulatory and metabolic effects of glucocorticoids.
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Weitere Beiträge
AUG
22
Advancing equity in genomic medicine for rheumatology
By:
Roberto Díaz-Peña
on
AUG
22
Nature Reviews Rheumatology, Published online: 22 August 2024; doi:10.1038/s41584-024-01156-yIncreasing diversity in genomic studies is essential to advance precision medicine and health equity in rheumatic diseases. Addressing structural and logistical barriers to include underrepresented populations, particularly in Africa and Latin America, could improve our understanding of rheumatic diseases and lead to better healthcare outcomes for all.
Mehr lesen >>
AUG
20
PDZK1 downregulation linked to mitochondrial dysfunction in OA
By:
Maria Papatriantafyllou
on
AUG
20
Nature Reviews Rheumatology, Published online: 20 August 2024; doi:10.1038/s41584-024-01157-xThe PDZ domain-containing scaffold protein PDZK1 is downregulated in osteoarthritic chondrocytes and is linked to mitochondrial dysfunction and chondrocyte senescence.
Mehr lesen >>
AUG
09
Ion channels in osteoarthritis: emerging roles and potential targets
By:
Renpeng Zhou
on
AUG
09
Nature Reviews Rheumatology, Published online: 09 August 2024; doi:10.1038/s41584-024-01146-0Ion channels have key functions in chondrocytes, bone cells, immune cells and neurons. Liu and colleagues discuss how these functions might contribute to cartilage degeneration, bone formation inflammation and pain in osteoarthritis, and highlight the therapeutic potential of ion channel modulators.
Mehr lesen >>
AUG
08
Behavioural therapy app for fibromyalgia
By:
Sarah Onuora
on
AUG
08
Nature Reviews Rheumatology, Published online: 08 August 2024; doi:10.1038/s41584-024-01151-3Behavioural therapy app for fibromyalgia
Mehr lesen >>
AUG
07
The past 25 years in paediatric rheumatology: insights from monogenic diseases
By:
Seza Ozen
on
AUG
07
Nature Reviews Rheumatology, Published online: 07 August 2024; doi:10.1038/s41584-024-01145-1Paediatric rheumatology has seen many notable developments in the past 25 years, including the introduction of the concept of autoinflammation and a greater understanding of the genetics and pathogenesis of inflammatory diseases. In this Perspective, Ozen and Aksentijevich discuss how these and other discoveries have transformed the field and herald improvements in patient care.
Mehr lesen >>
AUG
07
The role of obesity and adipose tissue dysfunction in osteoarthritis pain
By:
Marie Binvignat
on
AUG
07
Nature Reviews Rheumatology, Published online: 07 August 2024; doi:10.1038/s41584-024-01143-3In this Review, the authors explore the complex interactions between osteoarthritis-related pain and obesity, adipose tissue dysfunction and metabolic syndrome, and discuss how knowledge of these relationships could help improve pain management and identify new therapeutic options.
Mehr lesen >>
AUG
06
Advancements and challenges in CAR T cell therapy in autoimmune diseases
By:
Georg Schett
on
AUG
06
Nature Reviews Rheumatology, Published online: 06 August 2024; doi:10.1038/s41584-024-01139-zCAR T cell therapy shows promise for achieving long-term drug-free remission in various autoimmune diseases. This Review discusses the ongoing challenges and unanswered questions of CAR T cell therapy in autoimmune diseases, including pre-procedural, procedural and post-procedural considerations.
Mehr lesen >>
AUG
01
Shedding light onto the immunometabolic effects of glucocorticoids
By:
Luis M. Franco
on
AUG
01
Nature Reviews Rheumatology, Published online: 01 August 2024; doi:10.1038/s41584-024-01144-2Glucocorticoids are important anti-inflammatory and immunosuppressive drugs and potent regulators of metabolism. However, their immune and metabolic effects have been treated as separate entities. New research is shedding light onto the intersection between the immunoregulatory and metabolic effects of glucocorticoids.
Mehr lesen >>
Weitere Beiträge
Urologie
AUG
12
Field effect and forerunner genes drive bladder cancer initiation
By:
Maria Chiara Masone
on
AUG
12
Nature Reviews Urology, Published online: 12 August 2024; doi:10.1038/s41585-024-00929-0Field effect and forerunner genes drive bladder cancer initiation
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AUG
09
Utility of PSA screening in transgender women receiving oestrogens
By:
Maria Chiara Masone
on
AUG
09
Nature Reviews Urology, Published online: 09 August 2024; doi:10.1038/s41585-024-00930-7Utility of PSA screening in transgender women receiving oestrogens
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AUG
09
Single-cell analysis of advanced prostate cancer
By:
Louise Lloyd
on
AUG
09
Nature Reviews Urology, Published online: 09 August 2024; doi:10.1038/s41585-024-00933-4Single-cell analysis of advanced prostate cancer
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AUG
09
AI for drug discovery
By:
Louise Lloyd
on
AUG
09
Nature Reviews Urology, Published online: 09 August 2024; doi:10.1038/s41585-024-00931-6AI for drug discovery
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AUG
09
Urology’s carbon footprint
By:
Louise Lloyd
on
AUG
09
Nature Reviews Urology, Published online: 09 August 2024; doi:10.1038/s41585-024-00934-3Urology’s carbon footprint
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AUG
09
Immunotherapy for penile cancer
By:
Louise Lloyd
on
AUG
09
Nature Reviews Urology, Published online: 09 August 2024; doi:10.1038/s41585-024-00932-5Immunotherapy for penile cancer
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AUG
08
Accurate information provided by artificial intelligence
By:
Louise Lloyd
on
AUG
08
Nature Reviews Urology, Published online: 08 August 2024; doi:10.1038/s41585-024-00928-1Accurate information provided by artificial intelligence
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AUG
07
Neoadjuvant lutetium PSMA, the TIME and immune response in high-risk localized prostate cancer
By:
Renu S. Eapen
on
AUG
07
Nature Reviews Urology, Published online: 07 August 2024; doi:10.1038/s41585-024-00913-8Lutetium PSMA is approved for the treatment of advanced prostate cancer and is being studied in a neoadjuvant setting. The influence of lutetium PSMA on the tumour immune microenvironment is unknown. In selected patients, lutetium PSMA could be used as a stand-alone treatment or in combination with immunotherapy to produce long-lasting antitumour immunity.
Mehr lesen >>
Weitere Beiträge
AUG
12
Field effect and forerunner genes drive bladder cancer initiation
By:
Maria Chiara Masone
on
AUG
12
Nature Reviews Urology, Published online: 12 August 2024; doi:10.1038/s41585-024-00929-0Field effect and forerunner genes drive bladder cancer initiation
Mehr lesen >>
AUG
09
Utility of PSA screening in transgender women receiving oestrogens
By:
Maria Chiara Masone
on
AUG
09
Nature Reviews Urology, Published online: 09 August 2024; doi:10.1038/s41585-024-00930-7Utility of PSA screening in transgender women receiving oestrogens
Mehr lesen >>
AUG
09
Single-cell analysis of advanced prostate cancer
By:
Louise Lloyd
on
AUG
09
Nature Reviews Urology, Published online: 09 August 2024; doi:10.1038/s41585-024-00933-4Single-cell analysis of advanced prostate cancer
Mehr lesen >>
AUG
09
AI for drug discovery
By:
Louise Lloyd
on
AUG
09
Nature Reviews Urology, Published online: 09 August 2024; doi:10.1038/s41585-024-00931-6AI for drug discovery
Mehr lesen >>
AUG
09
Urology’s carbon footprint
By:
Louise Lloyd
on
AUG
09
Nature Reviews Urology, Published online: 09 August 2024; doi:10.1038/s41585-024-00934-3Urology’s carbon footprint
Mehr lesen >>
AUG
09
Immunotherapy for penile cancer
By:
Louise Lloyd
on
AUG
09
Nature Reviews Urology, Published online: 09 August 2024; doi:10.1038/s41585-024-00932-5Immunotherapy for penile cancer
Mehr lesen >>
AUG
08
Accurate information provided by artificial intelligence
By:
Louise Lloyd
on
AUG
08
Nature Reviews Urology, Published online: 08 August 2024; doi:10.1038/s41585-024-00928-1Accurate information provided by artificial intelligence
Mehr lesen >>
AUG
07
Neoadjuvant lutetium PSMA, the TIME and immune response in high-risk localized prostate cancer
By:
Renu S. Eapen
on
AUG
07
Nature Reviews Urology, Published online: 07 August 2024; doi:10.1038/s41585-024-00913-8Lutetium PSMA is approved for the treatment of advanced prostate cancer and is being studied in a neoadjuvant setting. The influence of lutetium PSMA on the tumour immune microenvironment is unknown. In selected patients, lutetium PSMA could be used as a stand-alone treatment or in combination with immunotherapy to produce long-lasting antitumour immunity.
Mehr lesen >>
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